Besides the fact that SCSI drives formated with sector sizes >512 bytes did work in the old days of OS7 (I tried that), I can report that a WD10EARS is doing fine in my MDD running Tiger.
Also, WDC says their "newly" formated drives are ok on
current Macs:
http://www.wdc.com/en/products/advancedformat/ It's not so much a question of hardware than of
software. In particular, performance hits. It works, it just sometimes can be
dog slow
