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I used it too for a while, as a mandatory corporate thing. Always kept it disabled! No problems. Got rid of it when switching to Leopard.
On one machine (PPC), I use ClamXAV (don't like it because it is very slow to update, and it does it every time I download something and it starts to scan), and iAntiVirus. The latter is my favorite - fast, unobtrusive and, by many reviews, reliable. Unfortunately, it won't work on a PPC, only on Intel.