TechToolPro can check and repair the directory, and I believe that Drive Genius can as well. As to your specific issue (and this happened awhile back when DW worked for pre-APFS volumes), I booted from an external drive and had to disable some Adobe activities via Console. I don't remember the specifics but a look at Console may give you some ideas. I had a senior moment while posting this. I should have said ACTIVITY MONITOR instead of Console. 
Jon
macOS 11.7.10, iMac Retina 5K 27-inch, late 2014, 3.5 GHz Intel Core i5, 1 TB fusion drive, 16 GB RAM, Epson SureColor P600, Photoshop CC, Lightroom CC, MS Office 365
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