Originally Posted by artie505
The icon drop-down specifically refers to content blockers, which suggests that other types of extensions are excluded from its functionality.
You are right — I was too focused on Content Blockers, but it is the content blockers that are most often the culprit or at least that has always worked for me.

The develop Menu is an all-or-nothing extension on-off for all sites while Safari > Preferences offers more nuanced control. Without the aid of the Develop Menu, Safari > Preferences > Extensions permits tuning off individual extensions including content blockers for all web sites and Safari > Preferences > Web sites permits site-by-site control of a wide variety of functions including permitting content blockers and other extensions.

I prefer a flyswatter to a howitzer for swatting annoyances. 😀

If we knew what it was we were doing, it wouldn't be called research, would it?

— Albert Einstein