Personally I use
PDF Pen 10 for that kind of work as I find it more precise, but it can be done in Preview. Assuming you have the Edit/annotate menu open
- On the preview Tool Bar click on the text box.
- Click somewhere on a blank part of the page, this will insert a text box
- Click on the word TEXT in the text box then type the letter X on our keyboard
- If the handles are not showing on the text box click on the text box frame
- Use the handles to size the fram appropriately
- With the handles still showing press Command+C (⌘C) to copy the text box onto the clipboard
- Press Command+V (⌘V) to create a new copy of the text box
- click anywhere on the page to clear the text box selection
- Click in the center of the new text box and drag it to the desired location.
- Repeat. steps 7 though 9 until all the proper locations have been marked.
If you are going to be doing this kind of thing a LOT you might want to consider
PDFPenPro 10. Although it is pricey it will convert any PDF into a form pretty accurately and then all you have to do is click on the checkbox in the form and it will automatically insert an X or ✔ It can make short work of an otherwise onerous and time consuming task.