I've got Cookie set to clear cache whenever I quit Safari, and I sometimes do interim command-option-E clears. (Note that you can't clear cache while Safari is running by any method other than that command.)
Another way is to use the Develop menu, which lists that keyboard shortcut as a reminder.
Why would I want to mouse up to my menu bar and click on "Develop" and then mouse down to and click on "Empty Caches" when there's a much quicker/easier key command?
I don't see the key command as a "reminder", but as a "
this is how you really do it".
And I'm sure there are many who don't agree.