I've got Cookie set to clear cache whenever I quit Safari, and I sometimes do interim command-option-E clears. (Note that you can't clear cache while Safari is running by any method other than that command.) Another way is to use the Develop menu, which lists that keyboard shortcut as a reminder.
Jon
macOS 11.7.10, iMac Retina 5K 27-inch, late 2014, 3.5 GHz Intel Core i5, 1 TB fusion drive, 16 GB RAM, Epson SureColor P600, Photoshop CC, Lightroom CC, MS Office 365
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