I'm using Safari 10 with newly installed macOS Sierra. So far with my financial logins, through 1PW, I've not experienced any issues. (I checked all this morning.)

I also use Ghostery and AdBlock (free versions) and also haven't experienced any differences than previously with Safari 9.x


MacStudio M1max - 14.4.1, 64 GB Ram, 4TB SSD; Studio Display; iPhone 13mini; Watch 9; iPadPro (M2) 11" WiFi