I assume that by "white list", you mean temporarily bypassing Gatekeeper (which prevents apps without an Apple certificate from launching). It's really easy to do on a case-by-case basis. Read How to bypass Gatekeeper in OS X Mavericks. Even though it says Mavericks, the same procedure applies to Yosemite and El Capitan.

I can't offer a suggestion about making a schedule to index Spotlight. AFIK, it updates itself automatically, on the fly.

Jon

macOS 11.7.10, iMac Retina 5K 27-inch, late 2014, 3.5 GHz Intel Core i5, 1 TB fusion drive, 16 GB RAM, Epson SureColor P600, Photoshop CC, Lightroom CC, MS Office 365