I'm having an issue occasionally where my mouse cursor doesn't change to a hand when mousing over hyperlinks in my web browser, making it difficult to know if I'm properly resting on the link to click it. Similarly, pull down menus don't highlight when hovering over menu commands.

Oddly, unplugging and replugging the mouse cable from the keyboard fixes it immediately until the next time it happens, which can be anywhere from a few minutes to over a day or so later. Seems completely random.

I'm running OS X Mavericks 10.9.5 on a 2011 21.5-inch iMac, with a Microsoft Intellimouse Explorer I've had for many years. I also use USB Overdrive and the problem cropped up sometime after upgrading to version 3.1 version, but downgrading back to 3.0.2 didn't fix it, so I hesitate to blame USB Overdrive.

Any ideas about what to do to fix this?