Maybe yes, maybe no.

My professional account is constantly bombarded with spam, all of which emanates from the same source under guise of separate entities. All the spam comes with Unsubscribe links which just verify my existence if responded to.

A number of similar sites have "do not reply" return addresses, no Unsubscribe link, only an Unsubscribe button which is most certain to put unwanted crap on one's computer or request privileged information.