It might also be of interest to look at your RAM memory usage when the spreadsheet is open. Depending on what formulas, etc. are involved, Excel may start to hog your memory and, independent of size, that could cause issues.
I tried it just now and no problem. That's probably due to the fact that a major portion is text that requires no calculations.
Mac Pro dual Quad-Core Intel Xeons Early 2008; 16GB RAM; MacOS X 10.11.6, iOS 9.3.5
