The first time I save a document in virtually any application, the delay before the save dialogue appears seems interminable -- in the case of "save as PDF" from the print dialogue, among others, the wait can be almost half a minute. There is a shorter 15 second delay before the contents of a secondary disk initially show up in a finder window, and in some applications (NoteTaker) before the list of recently viewed items appears in the File/Open drop down list.

All subsequent saves and opens (one application at a time!) are instantaneous per normal. I assume that means software, not hardware, is the culprit -- unless my Wacom Cintiq monitor, which will not let the computer sleep, could be at fault. Although I've had the problem from day one, I'm currently running OS 10.5.7 on a 2x3.2 GHz Quad-Core Intel Mac-Pro with 4 internal hard drives. I run Cocktail 4.3.3 pretty regularly.

Any help, including speculation, would be much appreciated.