I've always used command-option-E to empty Safari's cache (Safari 5.1.10 > Develop offers "Disable Cache", but not "Empty Cache".)
On the other hand, though, since Safari 5.0, my emptying cache via c-o-E has invariably resulted in Safari Web Content/WebProcess's crashing after a few emptyings.
The new Great Equalizer is the SEND button.
In Memory of Harv: Those who can make you believe absurdities can make you commit atrocities. ~Voltaire
