Every single day we get a spam email with heading "Factory Sealed MacBooks, iPads & Kindles Under $50!" and another one with heading "Learn to Cut Electric Bills by 90%".
Every day I blacklist them.
If you are using Apple's mail program, you can go to Preferences/Rules and find an excellent system for dealing with unwanted mail. I have found it very effective.
After I establish a rule I never see the spam again. If it does get sent to me, I hear the audible alert that mail has arrived but it never appears in my inbox. I've gone from receiving a fair amount of unwanted mail to possibly one or two in a week - that I quickly dispatch.