In preparation for Lion, I ran the ‘Find Orphans†option in AppDelete.
As expected, about 30 orphans were discovered. As AppDelete allows the orphan list to be sorted by date, a few of the really old orphans (going back to 2002) were easily deleted.
All remaining orphans are plists. But I do not know which ones are safe to delete. Is there a rule of thumb or some such that provides a bit of insight? I am not looking for a guarantee, just general counsel, advice, and gotchas to avoid.