I use MalwareBytes Mobile Security, but I have no idea if it works with Chrome or not, but I would think it more important that it works with the YouTube apps.
If we knew what it was we were doing, it wouldn't be called research, would it?
Thanks Joe I deleted the You Tube app as once in app you never get rid of ads unless you pay $10 month. So best solution adblock with Safari. If someone has something Chrome... not sure exist.