The only caveat that I can think of involves rebuilding the launch services database. That will reset the programs that open apps to their defaults. So, if you have specified that another program should open a file, you'll have to reset it. For example, if you have PDFs set to open with Adobe Reader, resetting the launch services database will reset that to Preview. You'll have to do a Get Info on a PDF, select AR from the Open With menu, and then click Change All.
Jon
macOS 11.7.10, iMac Retina 5K 27-inch, late 2014, 3.5 GHz Intel Core i5, 1 TB fusion drive, 16 GB RAM, Epson SureColor P600, Photoshop CC, Lightroom CC, MS Office 365
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