I just installed the 10.8.3 Combo update without issue. Well, if there are issues lurking, I have yet to discover them. Stay tuned…
Upon completing the first stage of the DL and install, the subsequent "double restart" was about twice the time for a normal restart, but typical for an update. Restarts since then have been normal.
Upon installation of 10.8.3, I ran DiskWarrior v4.4 from a different volume and much to my surprise, DW found nothing to fix.
I also ran the foreign languages removal via TinkerTool System v3.1 and, of course, there were numerous files to remove. Again, all went well (as expected).
And finally, I ran DU, and again, all was normal.
So for me, 'twas an easy & smooth update, but as yet, I see no benefits or detriments.
Indeed, I hope this update is equally trauma-free for you too.